Insights / Topics
What is real, what is theatre, and what will actually compound inside large pharma. From AI-assisted commercial strategy to regulated workflows, written from the inside.
AI is reshaping how drugs get discovered, developed, and reviewed, but the binding constraint is rarely the model. The recurring argument is that announcements, GPUs, and billion-dollar deals are the easy part; industrialization and getting large organizations to actually operate differently are the hard part. The sharper questions sit downstream: who captures the value, which business models survive, where AI is real versus theatre, and whether discovery gains matter when clinical cost is the real bottleneck.
28 May 2026 · 3 min read
At the AI in Clinical Development Summit we hosted in New York, one line defined the room: don't get out of bed for an AI project worth less than $100 million. I walked away with four ideas about where pharma's AI transformation is actually landing — and a conviction that regulatory submissions are heading toward agent-to-agent transactions built on machine-native data standards.
19 May 2026 · 3 min read
AstraZeneca's licensing of Owkin's K Pro platform signals where agentic AI is actually landing in pharma right now — competitive intelligence — not the broader scientific autonomy the positioning implies. I break down which workflows are realistic today and why the teams that start with unglamorous, high-leverage tasks will be best positioned when the harder problems become tractable.
12 May 2026 · 4 min read
Isomorphic Labs is in advanced talks to raise more than $2B, and I'm of two minds about it. The capital is welcome, but the deeper question is whether tech boards will stay patient through a decade of clinical iteration — and whether anyone is funding the downstream bottleneck that more AI-generated candidates will only tighten.
7 May 2026 · 3 min read
Most AI-first techbios are modeling clinical costs that are roughly half of what they will actually face — and the capital required to put an AI-derived molecule in front of a patient has roughly doubled within the lifespan of one mRNA company. Discovery cost reductions are real and welcome, but the binding constraint sits elsewhere.
5 May 2026 · 3 min read
Capital depth, role mix, and integration target. Three signals that separate a real pharma AI capability build from a press-release pilot dressed up as a strategic partnership.
30 Apr 2026 · 3 min read
The FDA's first real-time clinical trials don't just promise faster reviews — they insert a new infrastructure layer between sponsors and the agency. I break down what that architectural shift means for clinical development.
28 Apr 2026 · 3 min read
OpenEvidence has withdrawn from the EU and UK citing regulatory uncertainty around the EU AI Act, making the geography of clinical AI access officially American. I break down what this means for US and European pharma, and why the AI Act's first observable market effect may be pushing physicians toward less-grounded AI alternatives.
16 Apr 2026 · 3 min read
Last week, OpenAI made two moves in pharma within 48 hours — a flagship enterprise deal with Novo Nordisk and the launch of GPT-Rosalind — and the sequencing tells a deliberate story about how they're building a verticalised commercial infrastructure for life sciences. Having sat on the pharma buyer side, I break down what that cadence actually accomplishes.
14 Apr 2026 · 3 min read
The hyperscalers are moving on drug discovery from every direction — Anthropic acquired Coefficient Bio, and AWS just launched Amazon Bio Discovery with 40+ biological foundation models and integrated CRO partners. I still don't think the commercial model of pharma is under major threat, but the R&D part is clearly heating up massively.
7 Apr 2026 · 3 min read
Boehringer Ingelheim's new AI and machine learning center in London signals something more specific than another pharma AI announcement — pharma is starting to build permanent capability hubs, not just buy software deals. My bet is that by 2028, the companies with serious in-house computational capability will look structurally different from the ones that outsourced both talent and hardware.
2 Apr 2026 · 3 min read
CRO stocks dropped sharply on AI fears: IQVIA, Medpace, Charles River. The market may be right that AI changes trial economics. It’s wrong about where the disruption lands. CROs are infrastructure companies, and AI should make them more valuable, not less — if they can break free from the cost-plus model.
31 Mar 2026 · 3 min read
Eli Lilly’s third Insilico deal in three years: $115M upfront, up to $2.75B in milestones, plus royalties. The progression from software licensing in 2023 to a $2.75B commitment in 2026 tells the real story. The signal for the rest of the AI drug discovery space is harder to read — deals like this concentrate pharma attention on proven platforms.
26 Mar 2026 · 3 min read
A company you’ve most likely never heard of just raised $787M for AI-driven biologics. The headline number is striking. Sanofi’s trajectory — partner to repeat customer to investor in under twelve months — tells you more about the platform than any press release. The Delaware-incorporated, Beijing-operating structure is the emerging architecture for Chinese AI biotech going global.
17 Mar 2026 · 2 min read
Roche just announced pharma's largest hybrid-cloud AI factory, combining 2,176 new NVIDIA Blackwell GPUs with an existing footprint that now exceeds 3,500 across the U.S. and Europe. But after years of watching these waves from inside pharma, the pattern is clear: the announcement is the easy part — the hard part is getting a large organization to actually change how it works.
10 Mar 2026 · 4 min read
Three big AI drug discovery launches in 90 days: Boltz, IsoDDE, OpenFold3. Every benchmark was built by the team that built the model. The real question isn’t which model has the best benchmark. It’s whether discovery teams have a rigorous internal framework to evaluate any model that shows up. The real moat is evaluation discipline.
3 Mar 2026 · 2 min read
Lab-in-the-loop gets talked about like it’s a model problem. The Roche/Novartis/Microsoft panel at health.tech | global summit Basel made the real point clearer: it’s an operating model problem. Most orgs are at Level 1–2 maturity, and that’s already useful — the first big value isn’t more hits, it’s faster, more confident kill decisions.
26 Feb 2026 · 3 min read
Clarivate is selling its LS&H division — $390M in revenue, down 7% YoY, stock at $1.69. Decision Resources and Cortellis defined pharma intelligence for decades. GenAI-native platforms are now structuring, querying, and synthesizing across the same data at a fraction of the cost. When organized access to information is your moat, and AI organizes information better than you, that’s not a strategy problem. That’s an existential one.
24 Feb 2026 · 3 min read
Europe keeps asking “will AI in pharma R&D mean fewer jobs?” That’s the wrong question. The right one is who captures the value. Adoption is real but structurally slow. TechBio reshapes the pipeline economy. Data hunger grows. The real risk: while Europe debates headcount, the platforms and IP get built elsewhere.
19 Feb 2026 · 2 min read
Two pharma-AI deals in two weeks, two completely different architectures. Takeda paid $1.7B for Iambic. Now Merck skips techbio entirely and runs its AI models inside Mayo Clinic’s secure data environment. The architecture behind the Merck deal is what matters.
17 Feb 2026 · 2 min read
Barely a month goes by without another billion-dollar AI discovery deal. But Takeda’s deal with Iambic isn’t about buying AI — it’s about acquiring binding intelligence. If it works, portfolio strategy shifts from option value through volume to option value through precision. The hard part is industrializing it.
22 Jan 2026 · 2 min read
NVIDIA and Eli Lilly are putting $1B into a co-located Bay Area lab where Lilly scientists and NVIDIA engineers build drug discovery models side by side. Not a typical AI partnership. The real story is closed-loop discovery, and the moat is the loop, not the model.
6 Jan 2026 · 2 min read
Insilico Medicine closed 2025 with a ~US$293M HKEX IPO and opened 2026 with an $888M oncology collaboration with Servier — two major pharma deals in two months that suggest repeatable demand for their AI drug discovery platform.
5 Jan 2026 · 2 min read
I'm sharing my 5 bets for AI in Healthcare and TechBio in 2026 — from ambient scribes becoming table stakes to a TechBio Series B shakeout accelerating. If one of these is wrong, I want to know which one and what would change your mind.
11 Dec 2025 · 1 min read
My former colleagues at Novartis just signed a $1.7B deal with a seed-stage company — not for a drug or a molecule, but for targets. This signals a real shift in where pharma sees risk and is willing to pay in the value chain.
6 Nov 2025 · 1 min read
After working with both global pharma leaders and early-stage AI firms, I've seen a pattern: partnerships, done right, are the only scalable route to real-world adoption of AI.
4 Nov 2025 · 1 min read
Eli Lilly just moved from renting compute to owning it — 1,000+ Blackwell B300 GPUs in an on-prem DGX SuperPOD in Indianapolis. Their TuneLab initiative could turn R&D IT from a cost center into a deal channel, and it's further proof that pharma is finally taking AI seriously.
30 Oct 2025 · 1 min read
At the Global Health Exhibition in Riyadh, I moderated two panels bringing together top investors and operators to explore how AI can move from pilot to platform across pharma and care delivery — and the consensus was clear: execution, not technology, will define the winners of the next wave of digital health.
8 Oct 2025 · 3 min read
I joined an inspiring panel this morning at BioTechX with investors from Flagship Pioneering, Hikma Pharmaceuticals, MTIP, Lauxera Capital Partners, and Archimed to discuss where we stand on the journey of cracking biology and health with AI. From agentic AI and defensible moats to the tech-bio platform vs. pipeline dilemma and whether we're in an AI bubble, the conversation covered the full frontier.
6 Oct 2025 · 1 min read
I attended an exciting panel on GenAI's impact in preclinical development, featuring voices from Novartis, Insilico Medicine, and INVIDIA. Key themes included the balance of AI opportunity and risk, the power of robotics combined with AI, and the ongoing challenge of data organization and institutional memory in the lab.
6 Oct 2025 · 1 min read
I attended an interesting talk by Roche's Pierre Fischer at BioTechX about their Data Mesh Operating model, covering domain ownership, a dedicated data marketplace, and how their platform reduced dashboard delivery from months to under a week.
18 Jun 2025 · 1 min read
I joined an interesting discussion on AI in drug discovery and development at HLTHEurope2025 with panelists from Novartis, Roche, and OWKIN. From real-world evidence generation to biomarker development and regulatory considerations, the conversation covered both the opportunities and challenges of bringing AI into pharma.
6 Jun 2025 · 1 min read
I share a quick update on ELSA, the FDA's new GenAI tool powered by Anthropic's Claude, and why I genuinely appreciate the FDA's decision to launch it despite early imperfections — because in healthcare, the biggest challenge with new tech isn't the technology, it's the change management.
3 Jun 2025 · 1 min read
The FDA is now using GenAI to review regulatory dossiers — and I think that's a good thing. Pharma companies have already been using generative AI to craft submissions, so it makes perfect sense for regulators to leverage the same technology on their end.
13 May 2025 · 1 min read
Last week at the AI in Clinical Development Summit 2025 in NYC, I joined a panel tackling the timeless build-or-buy question for pharma AI in clinical development. Our consensus: a "build with" strategy — co-developing with selected strategic AI startup partners — strikes the right balance between speed, fit, and long-term value.
3 Apr 2025 · 1 min read
Google DeepMind's spin-off Isomorphic Labs has just raised $600M from Thrive Capital and GV, the latest mega-round in the blazing AI-enabled drug discovery space. I'm watching closely to see whether bigger funding truly translates to tangible clinical results in this rapidly emerging field.
14 Jan 2025 · 1 min read
One of the first tech-bio deals out of JPM this year sees Insilico Medicine and MENARINI Group deepen their partnership around an AI-discovered asset — not an AI platform — potentially worth up to $550M. I'm curious which business model will emerge as the leader for AI-techbio companies: selling AI platforms and services, or developing your own pipeline.
5 Dec 2024 · 1 min read
Interesting insights on the use of GenAI in Healthcare, from Bayer's Guido Mathews, Medtronic's Irina Evstifeeva and Karista's Amine Benmoussa at Health Tech Forward in Barcelona. From drug discovery and digital twins to medical imaging and workflow efficiency, the panel surfaced where GenAI is maturing — and where it still has a long way to go.
4 Dec 2024 · 1 min read
I attended a fascinating panel at Health Tech Forward on Automation in Clinical Trials featuring in-silico trials and digital twins. Speakers from QuantHealth, a leading VC, and United Therapeutics shared how AI is cutting trial lengths, replacing animal models, and opening new doors for orphan disease research.
18 Nov 2024 · 1 min read
Formation Bio, in collaboration with Sanofi and OpenAI, has introduced Muse, an AI-powered tool designed to optimize patient recruitment in clinical trials. I think it will be fascinating to watch how this three-party collaboration — Big Pharma, Health Tech, and Large Tech — evolves, and I wouldn't be surprised to see more of these partnerships emerge in the coming year.
9 Oct 2024 · 1 min read
A great talk from Gilead's Jeremy Zhang at BiotechX on scaling LLMs like OpenAI and Claude to the clinical portfolio — covering key use cases from protocol design to automated document generation, and the real hurdles of stakeholder skepticism and regulatory clarity.
9 Oct 2024 · 1 min read
I attended a fascinating panel on the Hype vs Hope of AI in Drug Discovery at BiotechX in Basel this morning. The conversation surfaced some sharp insights on where AI is genuinely moving the needle in drug discovery — and where the hype still outpaces reality.
9 Oct 2024 · 1 min read
At BiotechX in Basel, Gilead's Patrick Loerch outlined what it really takes for AI to create value in biopharma — from systemic business impact to decision-making influence. I found his take on centralized vs. distributed AI models, regulatory coordination, and clinical value chain opportunities particularly compelling.
20 Aug 2024 · 1 min read
I'm curious to see how the AI drug discovery space will evolve following the Recursion/Exscientia merger — and I'd personally bet on the traditional biotech drug-development model with AI enablement, rather than a pure SaaS or CRO play.
2 Jul 2024 · 1 min read
PharmaTech is increasingly becoming a category on its own, with PitchBook launching a dedicated research report and Q1 2024 seeing $749 million in funding across 39 deals. I think it's worth examining how they define the category, given the interesting mix of CDMO/CMO activities and AI enablement they cluster together.
1 May 2024 · 2 min read
I just got back from two packed days at LSX2024 in London, where I joined panels on pharma's path to launching digital health products and shared how QuantHealth will transform clinical trial design. Here are my key takeaways from the healthtech track.